A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

DNA and peptides are two of the most commonly used biomolecules for building self-
assembling materials, but few examples exist of hybrid nanostructures that contain both …

In nature, co-assembly of polypeptides, nucleic acids, and polysaccharides is used to create
functional supramolecular structures. Here, we show that DNA nanostructures can be used …

Natural cells can achieve specific cell–cell interactions by enriching nonspecific binding
molecules on demand at intercellular contact faces, a pathway currently beyond synthetic …

Coiled coils (CCs) are well‐understood protein‐folding motifs. They appear in a variety of
oligomer states and as homo‐and heteromeric assemblies. This versatility and the general …

Peptide heterodimers are prevalent in nature, which are not only functional macromolecules
but molecular tools for chemical and synthetic biology. Computational methods have also …

Abstract Coiled-coil (CC) dimer-forming peptides are attractive designable modules for
mediating protein association. Highly stable CCs are desired for biological activity regulation …

The protease inhibitors found in silkworm cocoons can be divided into several families, a
majority of which contain serpin, TIL, or Kunitz domains. Previously, it has been reported that …

β-Sheet motifs such as the WW domain are increasingly being explored as building blocks
for synthetic biological applications. Since the sequence-structure relationships of β-sheet …

There has been a recent surge in the design of miniproteins for medicinal chemistry,
biomaterial design, or synthetic biology. In particular, there is an interest in peptide scaffolds …