Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline

M Spinelli, S Fusco, C Grassi - Frontiers in neuroscience, 2019 - frontiersin.org
In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

The impact of free sugar on human health—a narrative review

KM Gillespie, E Kemps, MJ White, SE Bartlett - Nutrients, 2023 - mdpi.com
The importance of nutrition in human health has been understood for over a century.
However, debate is ongoing regarding the role of added and free sugars in physiological …

ACOD1 in immunometabolism and disease

R Wu, F Chen, N Wang, D Tang, R Kang - Cellular & molecular …, 2020 - nature.com
Immunometabolism plays a fundamental role in health and diseases and involves multiple
genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging …

Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases

EEM Leo, MRS Campos - Nutrition, 2020 - Elsevier
The current dietary pattern is characterized by high consumption of ultra-processed foods
and lower consumption of fiber and vegetables, environmental factors that are associated …

The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit

V Salas-Venegas, RP Flores-Torres… - Frontiers in Integrative …, 2022 - frontiersin.org
Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential

DJ Vesga-Jiménez, C Martin, GE Barreto… - International journal of …, 2022 - mdpi.com
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

Adipose tissue, systematic inflammation, and neurodegenerative diseases

APA Boleti, PHO Cardoso, BEF Frihling… - Neural Regeneration …, 2023 - journals.lww.com
Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

[HTML][HTML] Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila

S Liao, M Amcoff, DR Nässel - Insect biochemistry and molecular biology, 2021 - Elsevier
Excess consumption of high-fat diet (HFD) is likely to result in obesity and increases the
predisposition to associated health disorders. Drosophila melanogaster has emerged as an …

High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood …

O Bracko, LK Vinarcsik, JC Cruz Hernández… - Scientific reports, 2020 - nature.com
Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral
blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We …