The stiffness of living tissues and its implications for tissue engineering
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
Mechanical adaptability of tumor cells in metastasis
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …
successfully form life-threatening metastases when they undergo sequential steps along a …
Breast cancer models: Engineering the tumor microenvironment
The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …
development of clinically relevant models to study cancer biology and drug response in …
[图书][B] Atomic force microscopy
P Eaton, P West - 2010 - books.google.com
Atomic force microscopy is an amazing technique that allies a versatile methodology (that
allows measurement of samples in liquid, vacuum or air) to imaging with unprecedented …
allows measurement of samples in liquid, vacuum or air) to imaging with unprecedented …
If cell mechanics can be described by elastic modulus: study of different models and probes used in indentation experiments
Here we investigated the question whether cells, being highly heterogeneous objects, could
be described with the elastic modulus (effective Young's modulus) in a self-consistent way …
be described with the elastic modulus (effective Young's modulus) in a self-consistent way …
Application of atomic force microscopy in cancer research
X Deng, F Xiong, X Li, B Xiang, Z Li, X Wu… - Journal of …, 2018 - Springer
Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …
molecules. Recent advances have enabled its application in cancer research and diagnosis …
[HTML][HTML] In vitro cancer cell–ECM interactions inform in vivo cancer treatment
The general progression of cancer drug development involves in vitro testing followed by
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …
Forcing form and function: biomechanical regulation of tumor evolution
Cancer cells exist in a constantly evolving tissue microenvironment of diverse cell types
within a proteinaceous extracellular matrix. As tumors evolve, the physical forces within this …
within a proteinaceous extracellular matrix. As tumors evolve, the physical forces within this …
Review on cell mechanics: experimental and modeling approaches
ML Rodriguez, PJ McGarry… - Applied …, 2013 - asmedigitalcollection.asme.org
The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …
internally or that are externally applied to them play an important role in maintaining the …
Direct evidence that tumor cells soften when navigating confined spaces
The mechanical properties of cells strongly regulate many physiological and pathological
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
processes. For example, in cancer, invasive and metastatic tumor cells have often been …