Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment

V Bharadiya, Y Rong, Z Zhang, R Lin, AL Guerrerio… - Scientific reports, 2024 - nature.com
Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1
diabetes (T1D), including altered intestinal transcriptomes and protein expression …

[HTML][HTML] Intestinal microecology dysbiosis in inflammatory bowel disease: Pathogenesis and therapeutic strategies

Y Yin, W Feng, X Chen, J Chen, G Wang… - The Innovation …, 2024 - the-innovation.org
Inflammatory bowel disease (IBD) is an autoimmune disease characterized by non-
infectious, chronic, and recurrent inflammation in the intestine, with unclear pathogenesis …

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

KB Trang, P Sharma, L Cook, Z Mount, RM Thomas… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
A portion of the genetic basis for many common autoimmune disorders has been uncovered
by genome-wide association studies (GWAS), but GWAS do not reveal causal variants …

Shape Matters: Impact of Mesoporous Silica Nanoparticle Morphology on Anti-Tumor Efficacy

W Fang, K Yu, S Zhang, L Jiang, H Zheng, Q Huang… - Pharmaceutics, 2024 - mdpi.com
A nanoparticle's shape is a critical determinant of its biological interactions and therapeutic
effectiveness. This study investigates the influence of shape on the performance of …