Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

Hepatoblastomas (HBs) and pediatric hepatocellular carcinomas (HCCs) together account
for almost 80% of primary malignant liver tumors in children and adolescents/young adults …

Liver cancer is the second most common cause of cancer-related death. The major forms of
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …

Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …

Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-
activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize …

Pediatric hepatoblastoma is the most common primary liver cancer in infants and children.
Studies of hepatoblastoma that focus exclusively on tumor cells demonstrate sparse somatic …

Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …

Surgery and cisplatin‐based treatment of hepatoblastoma (HB) currently guarantee the
survival of 70%‐80% of patients. However, some important challenges remain in diagnosing …