An immunological perspective of circulating tumor cells as diagnostic biomarkers and therapeutic targets
Immune modulation is a hallmark of cancer. Cancer–immune interaction shapes the course
of disease progression at every step of tumorigenesis, including metastasis, of which …
of disease progression at every step of tumorigenesis, including metastasis, of which …
T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies
T cell dysfunction in glioblastoma: a barrier and an opportu... : Current Opinion in Neurology T cell
dysfunction in glioblastoma: a barrier and an opportunity for the development of successful …
dysfunction in glioblastoma: a barrier and an opportunity for the development of successful …
In vitro evidence for the potential of EGFR inhibitors to decrease the TGF-β1-induced dispersal of circulating tumour cell clusters mediated by EGFR overexpression
JD Hapeman, R Galwa, CS Carneiro, AM Nedelcu - Scientific Reports, 2024 - nature.com
Most cancer-related deaths are due to the spread of tumour cells throughout the body—a
process known as metastasis. While in the vasculature, these cells are referred to as …
process known as metastasis. While in the vasculature, these cells are referred to as …
A model for the dissemination of circulating tumour cell clusters involving platelet recruitment and a plastic switch between cooperative and individual behaviours
JD Hapeman, CS Carneiro, AM Nedelcu - BMC Ecology and Evolution, 2023 - Springer
Background In spite of extensive research, cancer remains a major health problem
worldwide. As cancer progresses, cells acquire traits that allow them to disperse and …
worldwide. As cancer progresses, cells acquire traits that allow them to disperse and …
[PDF][PDF] Phenotypic Plasticity during the Dissemination of Circulating Tumour Cell Clusters: A Model Involving TGFβ1-Mediated Cluster Dissociation, Adherence and …
JD Hapeman, CS Carneiro, AM Nedelcu - 2022 - preprints.org
Metastasis–the ability of cancer cells to disperse and colonize distant locations in the body,
is responsible for the majority of cancer-related deaths. While in the vasculature, tumour …
is responsible for the majority of cancer-related deaths. While in the vasculature, tumour …
Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
AM Cruz - 2021 - dspace.mit.edu
In genetically engineered mouse models of lung adenocarcinoma (LUAD), tumors become
more heterogeneous and dysregulate cell identities as they progress and evolve. In this …
more heterogeneous and dysregulate cell identities as they progress and evolve. In this …