The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The epicardial epithelial-mesenchymal transition (EMT) is hypothesized to generate
cardiovascular progenitor cells that differentiate into various cell types, including coronary …

Over the years, many apparently contradictory findings and functions have been ascribed to
the protein product of the WT1 tumour suppressor gene. These include being a …

WT1 was first identified as a tumor suppressor involved in the development of Wilms' tumor.
Recently, oncogenic properties of WT1 have been demonstrated in various hematological …

The glomerulus of the mammalian kidney is an intricate structure that contains an unusual
filtration barrier that retains higher molecular weight proteins and blood cells in the …

Sarcomas comprise some of the most aggressive solid tumours that, for the most part,
respond poorly to chemo‐and radiation therapy and are associated with a sombre prognosis …

Adrenal glands and gonads share a common primordium (AGP), but the molecular events
driving differentiation are poorly understood. Here we demonstrate that the Wilms tumor …

The expression of the Wilms' tumor gene WT1 was examined by immunohistochemistry in
40 cases of pancreatic ductal adenocarcinoma. WT1 protein was expressed in 30 (75%) of …

Expression of the Wilms' tumor gene WT1 in primary astrocytic tumors was examined using
a quantitative real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) or …