A substantial body of literature supports the intuitive notion that a good night's sleep can
facilitate human cognitive performance the next day. Deficits in attention, learning & memory …

Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented
the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Abstract Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized
in 1995. The generation of specific agonists, antagonists and receptor deficient mice and …

Sleep deprivation alters mood and anxiety in man. In rats, 24h of treadmill-induced total
sleep deprivation or sleep fragmentation increased exploratory behavior in an open field test …

Since the serendipitous discovery of the first class of modern antidepressants in the 1950's,
all pharmacotherapies approved by the Food and Drug Administration for major depressive …

Abstract Nociceptin/Orphanin FQ (N/OFQ) is an endogenous ligand of the N/OFQ peptide
(NOP) receptor, which is a G protein-coupled receptor in brain regions associated with mood …

Chronic hypercortisolemia is a hallmark of neuroendocrine and psychiatric disorders, such
as Cushing's disease and depression. Whether cortisol directly contributes to the altered …

The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …

Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin
opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence …