Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

BACKGROUND AND OBJECTIVES: Control of the intracellular Mycobacterium tuberculosis
(Mtb), mainly requires an appropriate ratio of Th1/Th2 cytokines to induce autophagy, a …

Background. Recent advances in rational adjuvant design and antigen selection have
enabled a new generation of vaccines with potential to treat and prevent infectious disease …

Tuberculosis is a human disease caused by infection with Mycobacterium tuberculosis. M.
tuberculosis (Mtb) is a facultative intracellular pathogen. The alveolar macrophages provide …

The challenge now is to validate the suggested biomarkers being described and then
reduce them to clinical practice. If this can be done, it offers the possibility of greatly …

The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report
that IL‐4 has a profound regulatory effect on the infection of BALB/c mice with …

It has been clearly demonstrated that in vitro, virulent M. tuberculosis can favor necrosis over
apoptosis in infected macrophages, and this has been suggested as a mechanism for …

Objectives Detailed understanding of tuberculosis (TB) immunopathology and
cytokine/chemokine responses can ultimately lead to the development of new diagnostic …