Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

A Marra, D Trapani, G Viale, C Criscitiello… - NPJ breast …, 2020 - nature.com
Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple
entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite …

Recent advances in the treatment of breast cancer

CWS Tong, M Wu, WCS Cho, KKW To - Frontiers in oncology, 2018 - frontiersin.org
Breast cancer (BC) is the most common malignancy in women. It is classified into a few
major molecular subtypes according to hormone and growth factor receptor expression …

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

A Lin, C Li, Z Xing, Q Hu, K Liang, L Han, C Wang… - Nature cell …, 2016 - nature.com
Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert
their functions in many biological processes, their potential involvement in cytoplasmic …

Antibody-drug conjugates in cancer therapy

EL Sievers, PD Senter - Annual review of medicine, 2013 - annualreviews.org
An antibody-drug conjugate (ADC) provides the possibility of selectively ablating cancer
cells by combining the specificity of a monoclonal antibody (mAb) for a target antigen with …

Triple negative breast cancer: a review of present and future diagnostic modalities

SA Dass, KL Tan, R Selva Rajan, NF Mokhtar… - Medicina, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no
expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal …

Triple-negative breast cancer: promising prognostic biomarkers currently in development

J Sukumar, K Gast, D Quiroga, M Lustberg… - Expert review of …, 2021 - Taylor & Francis
Introduction: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer
associated with poor prognosis and limited treatment options. Validated prognostic and …

A review of systemic treatment in metastatic triple-negative breast cancer

SB Zeichner, H Terawaki… - Breast cancer: basic and …, 2016 - journals.sagepub.com
Patients with breast cancer along with metastatic estrogen and progesterone receptor
(ER/PR)-and human epidermal growth factor receptor 2 (HER2)-negative tumors are …

[HTML][HTML] Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

RS O'Neill, A Stoita - World journal of gastroenterology, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …

Biomarkers in triple-negative breast cancer: state-of-the-art and future perspectives

S Cocco, M Piezzo, A Calabrese, D Cianniello… - International journal of …, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by
aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is still …

Novel antibody–drug conjugates for triple negative breast cancer

A Nagayama, N Vidula, L Ellisen… - … advances in medical …, 2020 - journals.sagepub.com
Triple negative breast cancer (TNBC) is a heterogenous subtype of breast cancer often
associated with an aggressive phenotype and poor prognosis. Antibody–drug conjugate …