Parkinson's disease (PD) is a deliberately progressive neurological disorder, arises due to
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The …

Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

The NLRP3 inflammasome signaling pathway is a major contributor to the
neuroinflammatory process in the central nervous system. Oxidative stress and …

Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal
to human health. Mn is present at low concentrations in a variety of dietary sources, which …

Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …

Epidemiological and clinical studies have long shown that exposure to high levels of heavy
metals are associated with increased risks of neurodegenerative diseases. It is widely …

Background The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-
dependent pyroptosis has been shown to play a vital role in the pathology of manganese …

Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), cobalt (Co), copper (Cu),
manganese (Mn), zinc (Zn), and others, have a significant impact on the development and …