Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

With the rapid development of genomic DNA sequencing, recombinant DNA expression,
and protein engineering, biocatalysis has been increasingly and widely adopted in the …

Biocatalyzed asymmetric reduction of ketones is an environmentally friendly approach and
one of the most cost-effective routes for producing chiral alcohols. In comparison with the …

Owing to its associated advantages such as the generation of two stereocenters in 100%
maximum theoretical yield, mild reaction conditions and environmentally friendliness …

Hydroxylation reaction is a significant source of structural diversity in natural products (NPs),
playing a crucial role in improving the bioactivity, solubility, and stability of natural product …

Ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) of α-
substituted-β-keto arylphosphonates was developed as a generic and stereoselective …

Abstract Development of an efficient, stereoselective, sustainable synthesis of chiral aryl β‐
hydroxy α‐amino acids and their derivatives is of paramount importance, owing to the broad …

Multiple stereoisomers can be found when a substance contains chiral carbons in its
chemical structure. To obtain the desired stereoisomers, asymmetric synthesis was …