Chemotherapy may have detrimental effects on either the central or peripheral nervous
system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a …

Leptomeningeal metastasis (LM) results from dissemination of cancer cells to both the
leptomeninges (pia and arachnoid) and cerebrospinal fluid (CSF) compartment. Breast …

Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the
leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung …

Intrathecal (IT) chemotherapy is an important component of the prophylaxis or treatment of
hematologic malignancies in the central nervous system (CNS), especially in patients with …

PURPOSE This study (Childrens Cancer Group [CCG]-105) was designed in part to
determine in a prospective randomized trial whether intrathecal methotrexate (IT MTX) …

Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated
with marked morbidity and mortality. The contemporary diagnostic and therapeutic …

Opinion statement Improvements in systemic therapy in the treatment of acute lymphoblastic
leukemia (ALL) and acute myeloid leukemia (AML) have improved patient outcomes and …

Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer are at
a particularly high risk of breast cancer brain metastasis (BCBM) and leptomeningeal …

Purpose Leptomeningeal disease (LMD) is an advanced metastatic disease presentation
portending a poor prognosis with minimal treatment options. The advent and widespread …

Methotrexate and cytarabine arabinoside are frequently administered intrathecally in the
prophylaxis and treatment of patients with hematological malignancies. Myelopathy as a …