SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

SUMMARY Extraintestinal pathogenic Escherichia coli (ExPEC) strains are responsible for a
majority of human extraintestinal infections globally, resulting in enormous direct medical …

The increasing incidence of carbapenem-resistant Enterobacteriaceae (CRE)-mediated
hospital infections in China prompted a need to investigate the genetic basis of emergence …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …

Antibiotics are an essential tool of modern medicine, contributing to significantly decreasing
mortality and morbidity rates from infectious diseases. However, persistent misuse of these …

To estimate the incidence of carbapenem-resistant Enterobacterales (CRE), a global
collection of 81,781 surveillance isolates of Enterobacterales collected from patients in 39 …

The emergence of carbapenem-resistant enterobacterial species poses a serious threat to
public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …