Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell
polarity. The cell polarity established in early embryos prefigures the macroscopic …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …

As highlighted by recent genome-wide analyses in diverse organisms and cell types,
subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish …

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins
locally, but has only recently emerged as a prevalent mechanism used by a wide variety of …

Polarized epithelial cells have a distinctive apical–basal axis of polarity for vectorial
transport of ions and solutes across the epithelium. In contrast, migratory mesenchymal cells …

RNA localization pathways direct numerous mRNAs to distinct subcellular regions and affect
many physiological processes. In one such pathway the tumor-suppressor protein …

The evolutionarily conserved Crumbs protein complex is a key regulator of cell polarity and
cell shape in both invertebrates and vertebrates. The important role of this complex in …

Stress granules (SGs) and P-bodies (PBs) are related cytoplasmic structures harboring
silenced mRNAs. SGs assemble transiently upon cellular stress, whereas PBs are …

Basement membranes (BMs) are specialized extracellular matrices that are essential for
epithelial structure and morphogenesis. However, little is known about how BM proteins are …