Overview of systems biology and omics technologies

B Karahalil - Current medicinal chemistry, 2016 - ingentaconnect.com
Traditional technologies using reductionist approach are relatively insufficient to solve
problems in a biological system. Rather than a reductionist approach, systems biology uses …

Quantitative disease resistance: dissection and adoption in maize

Q Yang, P Balint-Kurti, M Xu - Molecular plant, 2017 - cell.com
Maize is the world's most produced crop, providing food, feed, and biofuel. Maize production
is constantly threatened by the presence of devastating pathogens worldwide …

[HTML][HTML] Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

A Griciuc, A Serrano-Pozo, AR Parrado, AN Lesinski… - Neuron, 2013 - cell.com
The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that
regulates innate immunity but has no known functions in the brain. We have previously …

Genome-wide SNP detection, validation, and development of an 8K SNP array for apple

D Chagné, RN Crowhurst, M Troggio, MW Davey… - PloS one, 2012 - journals.plos.org
As high-throughput genetic marker screening systems are essential for a range of genetics
studies and plant breeding applications, the International RosBREED SNP Consortium …

Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia

E Reshetnikov, O Zarudskaya… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim The aim of this study was to examine the role of hereditary thrombophilia in the
development of fetal growth retardation (FGR) in the population of Central Russia. Methods …

Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children

S Esposito, CG Molteni, S Giliani, C Mazza, A Scala… - Virology journal, 2012 - Springer
Abstract Background Toll-like receptors (TLRs) form an essential part of the innate immune
system, which plays a fundamental role in rapidly and effectively controlling infections and …

The genetic side of type 2 diabetes–a review

S Cuschieri - Diabetes & Metabolic Syndrome: Clinical Research & …, 2019 - Elsevier
Abstract Aim Type 2 diabetes (T2DM) is a complex disease. Interactions between genetic
susceptible variants and environmental cues results in the development of this …

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

C Reed, H Baba, Z Zhu, J Erk, JR Mootz… - Frontiers in …, 2018 - frontiersin.org
Major gene effects on traits associated with substance use disorders are rare. Previous
findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary …

An elegant biosensor molecular beacon probe: challenges and recent solutions

DM Kolpashchikov - Scientifica, 2012 - Wiley Online Library
Molecular beacon (MB) probes are fluorophore‐and quencher‐labeled short synthetic DNAs
folded in a stem‐loop shape. Since the first report by Tyagi and Kramer, it has become a …

NGS-based genotyping, high-throughput phenotyping and genome-wide association studies laid the foundations for next-generation breeding in horticultural crops

N D'Agostino, P Tripodi - Diversity, 2017 - mdpi.com
Demographic trends and changes to climate require a more efficient use of plant genetic
resources in breeding programs. Indeed, the release of high-yielding varieties has resulted …