Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

Caloric restriction promotes longevity in multiple animal models. Compounds modulating
nutrient-sensing pathways have been suggested to reproduce part of the beneficial effect of …

Aging results in a decline of cellular proteostasis capacity which culminates in the
accumulation of phototoxic material, causing the onset of age-related maladies and …

Many common chronic diseases and syndromes are ageing-related. This raises the
prospect that therapeutic agents that target the biological changes of ageing will prevent or …

Background: Several clinical trials have suggested that resveratrol has hypoglycemic
properties; however, there are other studies in which such an effect has not been observed …

Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-
inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and …

Background Osteoporosis is a highly prevalent disease with distinct sex pattern. We aimed
to estimate the sex specific incidence, prevalence, and disability-adjusted life (DALYs) years …

Ovarian reserve is a term used to estimate the total number of immature follicles present in
the ovaries. Between birth and menopause, there is a progressive decrease in the number …