Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

Contraction of striated muscles is driven by cyclic interactions of myosin head projecting
from the thick filament with actin filament and is regulated by Ca2+ released from …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Troponin is essential in Ca2+ regulation of skeletal and cardiac muscle contraction. It
consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on …

In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+
binding to members of the EF hand family of proteins controls the interaction between actin …

Hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in the
young, is an autosomal dominant disease characterized by ventricular hypertrophy …

Myocardial stunning is characterized by decreased myofilament Ca sup 2+ responsiveness.
To investigate the molecular basis of stunned myocardium, we performed PAGE and …

The interaction of troponin-C (TnC) with troponin-I (TnI) plays a central role in skeletal and
cardiac muscle contraction. We have recently shown that the binding of Ca2+ to cardiac TnC …

Fourteen monoclonal antibodies (mAbs) against human cardiac troponin I (cTnI) were
generated by commonly used experimental techniques. All these antibodies, as well as …