NCCN guidelines insights: head and neck cancers, version 2.2017

D Adelstein, ML Gillison, DG Pfister, S Spencer… - Journal of the National …, 2017 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck
Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx …

Prognostic significance of extranodal extension in HPV-mediated oropharyngeal carcinoma: a systematic review and meta-analysis

L Benchetrit, SJ Torabi, B Givi… - … –Head and Neck …, 2021 - journals.sagepub.com
Objective To determine the prognostic role of extranodal extension (ENE) among patients
with human papilloma virus–positive (HPV+) oropharyngeal squamous cell carcinoma …

De‐intensified adjuvant (chemo) radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV‐positive …

J Howard, RC Dwivedi, L Masterson… - Cochrane Database …, 2018 - cochranelibrary.com
Background More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are
diagnosed every year worldwide and this is rising. Much of the increase has been attributed …

Detectable postoperative circulating tumor human papillomavirus DNA and association with recurrence in patients with HPV-associated oropharyngeal squamous cell …

DM Routman, S Kumar, BS Chera, KR Jethwa… - International Journal of …, 2022 - Elsevier
Purpose The purpose of our study is to determine the rate of detectability of ctHPVDNA after
surgery but before adjuvant therapy in patients with human papillomavirus (HPV)-associated …

The role of surgery and deescalation for HPV‐related oropharyngeal cancer

KJ Contrera, MR Patel, B Burtness, R Mehra… - Cancer, 2025 - Wiley Online Library
Recently published and ongoing trials are helping to define the role of transoral robotic
surgery for oropharyngeal cancer. Evidence to date supports the use of surgery as a …

Association of extracapsular spread with survival according to human papillomavirus status in oropharynx squamous cell carcinoma and carcinoma of unknown …

N Kharytaniuk, P Molony, S Boyle… - … –Head & Neck …, 2016 - jamanetwork.com
Importance The presence of extracapsular spread (ECS) of metastatic nodes is considered a
poor prognosticator in head and neck cancer, with postoperative chemoradiation therapy …

Inter-and intra-observer variability in the classification of extracapsular extension in p16 positive oropharyngeal squamous cell carcinoma nodal metastases

JS Lewis Jr, Y Tarabishy, J Luo, H Mani, JA Bishop… - Oral oncology, 2015 - Elsevier
Objective Discern inter-and intra-observer variability in the classification of extracapsular
extension (ECE) in p16+ oropharyngeal (OP) SCC comparing pathologists' own criteria …

Decreasing treatment burden in HPV-related OPSCC: A systematic review of clinical trials

GC Iorio, F Arcadipane, S Martini, U Ricardi… - Critical reviews in …, 2021 - Elsevier
Introduction Favorable outcomes are observed after treatment with standard
chemoradiotherapy (CRT) for Human papillomavirus (HPV)-related oropharyngeal …

Transoral resection of human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx: outcomes with and without adjuvant therapy

RS Jackson, P Sinha, J Zenga, D Kallogjeri… - Annals of surgical …, 2017 - Springer
Background With the rise of oropharyngeal squamous cell carcinoma associated with
human papillomavirus (HPV), appropriate treatment strategies continue to be tailored toward …

The role of adjuvant chemotherapy in surgically managed, p16-positive oropharyngeal squamous cell carcinoma

SA Skillington, D Kallogjeri, JS Lewis… - … –Head & Neck Surgery, 2017 - jamanetwork.com
Importance Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma
(OPSCC) has a favorable prognosis, and p16 immunohistochemistry is a surrogate marker …