Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

The genomic complexity of profound copy number aberrations has prevented effective
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …

In our previous study, we reported that sirtuin5 (SIRT5), a member of the NAD+-dependent
class III histone deacetylase family, is highly expressed in colorectal cancer (CRC). Herein …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

The laboratory mouse ranks among the most important experimental systems for biomedical
research and molecular reference maps of such models are essential informational tools …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …