Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection

K Bhatt, M Bhagavathula, S Verma… - Disease models & …, 2021 - journals.biologists.com
Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment.
Inadequate treatment can lead to relapse and the development of drug resistance TB …

A novel para-amino salicylic acid magnesium layered hydroxide nanocomposite anti-tuberculosis drug delivery system with enhanced in vitro therapeutic and anti …

B Saifullah, P Arulselvan, ME El Zowalaty… - International Journal …, 2021 - Taylor & Francis
Introduction Mycobacterium tuberculosis infections are associated with severe local
inflammatory reactions, which may be life-threatening and lead to tuberculosis pathogenesis …

Efficacy of vitamin D supplements in treatment of acute respiratory infection: a meta-analysis for randomized controlled trials

H Cho, SK Myung, HE Cho - Nutrients, 2022 - mdpi.com
Background: Recent randomized controlled trials (RCTs) have reported inconsistent findings
regarding the efficacy of vitamin D supplementation in the treatment of acute respiratory …

Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation

S Mo, X Liu, K Zhang, W Wang, Y Cai… - Journal of Leukocyte …, 2022 - academic.oup.com
Tuberculosis (TB), an infectious bacterial disease caused by Mycobacterium tuberculosis
(Mtb), is a major cause of death worldwide. Multidrug-resistant TB remains a public health …

Recombinant human lactoferrin reduces inflammation and increases fluoroquinolone penetration to primary granulomas during mycobacterial infection of C57Bl/6 …

TKT Nguyen, Z Niaz, ML Kruzel, JK Actor - Archivum immunologiae et …, 2022 - Springer
Abstract Infection with Mycobacterium tuberculosis (Mtb) results in the primary formation of a
densely packed inflammatory foci that limits entry of therapeutic agents into pulmonary sites …

The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis

C Cahill, DJ Cox, F O'Connell, SA Basdeo… - International Journal of …, 2021 - mdpi.com
Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-
resistant TB undergo long, arduous, and complex treatment regimens, often involving …

Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: A double blinded randomized control clinical …

S Sinha, H Thukral, I Shareef, D Desai, BK Singh… - PLoS …, 2023 - journals.plos.org
Background The immunomodulatory effects of vitamin D are widely recognized and a few
studies have been conducted to determine its utility in the treatment of tuberculosis, with …

Adjunct n-3 long-chain polyunsaturated fatty acid treatment in tuberculosis reduces inflammation and improves anemia of infection more in C3HeB/FeJ mice with low n …

FEA Hayford, RC Dolman, M Ozturk, A Nienaber… - Frontiers in …, 2021 - frontiersin.org
Populations at risk for tuberculosis (TB) may have a low n-3 polyunsaturated fatty acid
(PUFA) status. Our research previously showed that post-infection supplementation of n-3 …

The manipulation of the lipid mediator metabolism as adjunct host-directed therapy in tuberculosis

A Nienaber, FEA Hayford, E Variava… - Frontiers in …, 2021 - frontiersin.org
Host-directed therapies (HDTs) enhance the host response to tuberculosis (TB) infection to
reduce disease severity. For instance, the manipulation of lipid mediator production …

[PDF][PDF] Global scenario and recent advances in molecular diagnosis and management of drug-resistant tuberculosis

M Sannathimmappa, PG Parameshwara… - …, 2021 - researchgate.net
Tuberculosis (TB) is one of the oldest communicable bacterial diseases, spreads
predominantly by inhalation of infected respiratory droplets. It is a curable and preventable …