Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …
antibodies. Recently, aptamers have garnered increased interest due to their unique …
Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing
Detection of analytes by means of field-effect transistors bearing ligand-specific receptors is
fundamentally limited by the shielding created by the electrical double layer (the “Debye …
fundamentally limited by the shielding created by the electrical double layer (the “Debye …
Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
SELEX: Critical factors and optimization strategies for successful aptamer selection
M Kohlberger, G Gadermaier - Biotechnology and applied …, 2022 - Wiley Online Library
Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
Machine learning guided aptamer refinement and discovery
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high
affinity and specificity. They are typically discovered by searching large libraries for …
affinity and specificity. They are typically discovered by searching large libraries for …
ABCs of DNA aptamer and related assay development
TK Sharma, JG Bruno, A Dhiman - Biotechnology advances, 2017 - Elsevier
This review is intended to guide the novice in aptamer research and development to
understand virtually all of the aptamer development options and currently available assay …
understand virtually all of the aptamer development options and currently available assay …
In vitro evolution of ribonucleases from expanded genetic alphabets
CA Jerome, S Hoshika, KM Bradley… - Proceedings of the …, 2022 - National Acad Sciences
The ability of nucleic acids to catalyze reactions (as well as store and transmit information) is
important for both basic and applied science, the first in the context of molecular evolution …
important for both basic and applied science, the first in the context of molecular evolution …
Development of better aptamers: structured library approaches, selection methods, and chemical modifications
Systematic evolution of ligands by exponential enrichment (SELEX) has been used to
discover thousands of aptamers since its development in 1990. Aptamers are short single …
discover thousands of aptamers since its development in 1990. Aptamers are short single …