Natural killer (NK) cells have been used in several clinical trials as adaptive immunotherapy.
The low numbers of these cells in peripheral blood mononuclear cells (PBMC) have resulted …

Most patients who require allogeneic stem cell transplantation do not have a matched
sibling donor, and many patients do not have a matched unrelated donor. In an effort to …

Twenty-three children with nonmalignant disorders received HLA-haploidentical
hematopoietic stem cell transplantation (haplo-HSCT) after ex vivo elimination of αβ+ T cells …

Posttransplant relapse is still the major cause of treatment failure in high-risk acute
leukemia. Attempts to manipulate alloreactive T cells to spare normal cells while killing …

Allogeneic stem cell transplantation (allo-SCT) is a curable method for the treatment of
hematological malignancies. In the past two decades, the establishment of haploidentical …

In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than
one donor. A key issue in the haplo-SCT setting is the search for the best donor, because …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) have been shown to effectively
prevent graft-versus-host disease (GVHD) when adoptively transferred in murine models of …

T-cell depletion of an HLA-haploidentical graft is often used to prevent GVHD, but the
procedure may lead to increased graft failure, relapse and infections due to delayed immune …

Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in
eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding …

The present review describes the biology of human leukocyte antigen haplotype
mismatched (“haploidentical”) transplantation, its translation to clinical practice to cure …