Mechanisms of immune activation and regulation: lessons from melanoma

S Kalaora, A Nagler, JA Wargo, Y Samuels - Nature Reviews Cancer, 2022 - nature.com
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …

Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank

JD Szustakowski, S Balasubramanian, E Kvikstad… - Nature …, 2021 - nature.com
Abstract The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …

The person-to-person transmission landscape of the gut and oral microbiomes

M Valles-Colomer, A Blanco-Míguez, P Manghi… - Nature, 2023 - nature.com
The human microbiome is an integral component of the human body and a co-determinant
of several health conditions,. However, the extent to which interpersonal relations shape the …

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

JA McCulloch, D Davar, RR Rodrigues, JH Badger… - Nature medicine, 2022 - nature.com
Ample evidence indicates that the gut microbiome is a tumor-extrinsic factor associated with
antitumor response to anti-programmed cell death protein-1 (PD-1) therapy, but …

VFDB 2022: a general classification scheme for bacterial virulence factors

B Liu, D Zheng, S Zhou, L Chen… - Nucleic acids research, 2022 - academic.oup.com
The virulence factor database (VFDB, http://www. mgc. ac. cn/VFs/) is dedicated to
presenting a comprehensive knowledge base and a versatile analysis platform for bacterial …

Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome

S Nayfach, D Páez-Espino, L Call, SJ Low… - Nature …, 2021 - nature.com
Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

MC Andrews, CPM Duong, V Gopalakrishnan… - Nature medicine, 2021 - nature.com
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …

[HTML][HTML] Gut-microbiota-targeted diets modulate human immune status

HC Wastyk, GK Fragiadakis, D Perelman, D Dahan… - Cell, 2021 - cell.com
Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we
determined how two microbiota-targeted dietary interventions, plant-based fiber and …

[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

The integrative human microbiome project

HMP Integrative, LM Proctor, HH Creasy… - …, 2019 - ui.adsabs.harvard.edu
Abstract The NIH Human Microbiome Project (HMP) has been carried out over ten years and
two phases to provide resources, methods, and discoveries that link interactions between …