The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

Diabetes is a major public health disease that is globally approaching epidemic proportions.
One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin …

Pyroptosis is a form of cell death mediated by gasdermin D (GSDMD); it is characterised by
NLRP3 inflammasome activation, caspase activation, cell membrane pore formation, and …

Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface.
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …

Abstract FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-
membrane protein, and mediates the formation of mitochondria-associated endoplasmic …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Retinal degenerative diseases, such as age-related macular degeneration, retinitis
pigmentosa, diabetic retinopathy or glaucoma, represent the main causes of a decreased …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …