Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Alzheimer's disease (AD) is the most common cause of dementia and a great
socioeconomic burden in the aging society. Compelling evidence demonstrates that …

Compelling preclinical and clinical evidence supports a pathophysiological connection
between Alzheimer's disease (AD) and diabetes. Altered metabolism, inflammation, and …

Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …

Alzheimer's disease (AD) and diabetes are currently considered among the top threats to
human health worldwide. Intriguingly, a connection between these diseases has been …

The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …

The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …