Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged
as the most effective treatment for patients with metastatic melanoma and can mediate …

Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even
in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) …

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by
genetic modification of infused cells. However, oncogenic events due to vector/transgene …

Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the most established and
commonly used cellular immunotherapy in cancer care. It is the most potent anti-leukemic …

Over the last 60 years, more than a million patients received hematopoietic cell
transplantation. Having incorporated multiple changes in clinical practices, it remains a …

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …

The ability of allogeneic bone-marrow cells and peripheral-blood stem cells to cure
leukaemia remains the most striking example of the ability of the human immune system to …

Minor histocompatibility antigens (mHAs) are known targets of donor T cells after allogeneic
hematopoietic stem cell transplantation (HSCT). In contrast, B-cell responses to mHAs have …

There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …

The development of malignant disease might be seen as a failure of immune surveillance.
However, not all tumors are naturally immunogenic, and even among those that are …