In recent years, the deluge of complicated molecular and cellular microscopic images
creates compelling challenges for the image computing community. There has been an …

The past decade has seen an unprecedented data explosion in biology. It has become
evident that in order to take full advantage of the potential wealth of information hidden in the …

Using low-cost automated tracking microscopes, we have generated a behavioral database
for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described …

The ability to optically excite or silence specific cells using optogenetics has become a
powerful tool to interrogate the nervous system. Optogenetic experiments in small organisms …

Background Caenorhabditis elegans locomotion is a simple behavior that has been widely
used to dissect genetic components of behavior, synaptic transmission, and muscle function …

To the Editor—Animal behavior is increasingly being recorded in systematic imaging studies
that generate large datasets. To maximize the usefulness of these data, there is a need for …

This paper describes the fabrication of a microfluidic device for rapid immobilization of large
numbers of live C. elegans for performing morphological analysis, microsurgery, and …

This paper describes a new microfluidic platform for screening drugs and their dose
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …

A thorough understanding of nerve regeneration in Caenorhabditis elegans requires
performing femtosecond laser nanoaxotomy while minimally affecting the worm. We present …

The last half-century has provided all of the (few) drugs currently used to treat human
helminthiases. Concern regarding the long-term utility of these drugs, given how readily …