Potential and limits of (mal) adaptive mutation rate plasticity in plants
JG Monroe - New Phytologist, 2023 - Wiley Online Library
Genetic mutations provide the heritable material for plant adaptation to their environments.
At the same time, the environment can affect the mutation rate across plant genomes …
At the same time, the environment can affect the mutation rate across plant genomes …
Gene body methylation is under selection in Arabidopsis thaliana
In plants, mammals and insects, some genes are methylated in the CG dinucleotide context,
a phenomenon called gene body methylation (gbM). It has been controversial whether this …
a phenomenon called gene body methylation (gbM). It has been controversial whether this …
Report of mutation biases mirroring selection in Arabidopsis thaliana unlikely to be entirely due to variant calling errors
It has recently been proposed that the uneven distribution of epigenomic features might
facilitate reduced mutation rate in constrained regions of the Arabidopsis thaliana genome …
facilitate reduced mutation rate in constrained regions of the Arabidopsis thaliana genome …
Investigation Gene body methylation is under selection in Arabidopsis thaliana
In plants, mammals and insects, some genes are methylated in the CG dinucleotide context,
a phenomenon called gene body methylation. It has been controversial whether this …
a phenomenon called gene body methylation. It has been controversial whether this …
Convergent evolution of epigenome recruited DNA repair across the Tree of Life
Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA
repair can help organisms protect important genomic regions from mutation. However, the …
repair can help organisms protect important genomic regions from mutation. However, the …
The therapeutic potential of epigenome-modifying drugs in cardiometabolic disease
M Berjawi, CG Bell - Current Genetic Medicine Reports, 2021 - Springer
Abstract Purpose of Review Cardiometabolic disorders, including cardiovascular disease,
obesity and type 2 diabetes, are an extreme burden on the health of individuals and …
obesity and type 2 diabetes, are an extreme burden on the health of individuals and …
Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective
Evolutionary changes in brain and craniofacial development have endowed humans with
unique cognitive and social skills, but also predisposed us to debilitating disorders in which …
unique cognitive and social skills, but also predisposed us to debilitating disorders in which …