The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Since the development of metallopolymers, there has been tremendous interest in the
applications of this type of materials. The interest in these materials stems from their …

The ability of natural metalloproteins to prevent inactivation of their metal cofactors by
biological metabolites, such as glutathione, is an area that has been largely ignored in the …

Conspectus In nature, heme cofactor-containing proteins participate not only in electron
transfer and O2 storage and transport but also in biosynthesis and degradation. The …

An emerging approach in the field of targeted drug delivery is the establishment of abiotic
metal‐triggered prodrug mechanisms that can control the release of bioactive drugs …

The first example of a biocatalytic [2, 3]‐sigmatropic rearrangement reaction involving allylic
sulfides and diazo reagents (Doyle–Kirmse reaction) is reported. Engineered variants of …

Olefin metathesis is one of the most powerful C–C double-bond-forming reactions.
Metathesis reactions have had a tremendous impact in organic synthesis, enabling a variety …

The design of artificial enzymes has emerged as a promising tool for the generation of
potent biocatalysts able to promote new-to-nature reactions with improved catalytic …

Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C= C double bond in
α, β‐unsaturated compounds bearing an electron‐withdrawing group, for example, a …

Olefin metathesis has revolutionized synthetic approaches to carbon–carbon bond
formation. With a rich history beginning in industrial settings through its advancement in …