Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

Epigenetic alterations play an important role in tumor progression of diffuse large B-cell
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …

The survival of patients with oral squamous cell carcinoma (OSCC) has not changed
significantly in several decades, leading clinicians and investigators to search for promising …

Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is
characterized by the hallmark translocation t (11; 14)(q13; q32) and the resulting …

Notch signaling is often considered a model hematopoietic proto-oncogene because of its
role as the main trigger of T cell acute lymphoblastic leukemia (T-ALL). Although its role in T …

The Notch signaling pathway is a regulator of self-renewal and differentiation in several
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …

Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial
fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease …