The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

The complement system is a key component of innate host defence that, under normal
conditions, is responsible for the opsonization and destruction of potential pathogens …

Genetic adaptation to external stimuli occurs through the combined action of mutation and
selection. A central problem in genetics is to identify loci responsive to specific selective …

The lectin pathway of the complement system has a pivotal role in the defense against
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …

Complement is activated during malaria infection, but there is little evidence that it benefits
the host. On the contrary, growing evidence points to the central role of complement …

Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition.
Dysregulation of the complement system has been implicated, but molecular mechanisms …

Malaria remains one of the world's deadliest diseases. Plasmodium falciparum is
responsible for the most severe and lethal form of human malaria. P. falciparum's life cycle …

Plasmodium parasites cause malaria disease, one of the leading global health burdens for
humanity, infecting hundreds of millions of people each year. Different glycans on the …

Cerebral malaria (CM) is the most severe complication of malaria. The murine Plasmodium
berghei ANKA (PbA) infection model has helped to identify crucial players in the …

Background The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2)
encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in …