Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Cells have developed different mechanisms to respond to stress, including the formation of
cytoplasmic foci known as stress granules (SGs). SGs are dynamic and formed as a result of …

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions.
This can be achieved by the phosphorylation-mediated inactivation of a key translation …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

INTRODUCTION The recruitment of the ribosome to a specific mRNA is a critical step in the
production of proteins in cells. In addition to a general recognition of the “cap” structure at …

Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes.
CircRNAs are involved in a variety of physiological and pathological processes, but their …

Translation initiation of most mammalian mRNAs is mediated by a 5′ cap structure that
binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair …

Circular RNAs (circRNAs) are a new class of long non-coding RNAs that play a potential
role in gene expression regulation, acting as efficient microRNAs sponges. The latest …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …