Simple Summary Identification of mismatch repair-deficient tumors (MMRd), which occur in
up to 30% of all endometrial cancers (EC), has become unavoidable for therapeutic …

Purpose With the results of several recently published clinical trials, this guideline informs on
the use of adjuvant radiation therapy (RT) and systemic therapy in the treatment of …

Endometrial cancer is one of the most common cancers among women. The International
Collaboration on Cancer Reporting (ICCR) developed a standardized endometrial cancer …

Aims Microcystic, elongated, and fragmented (MELF) pattern of myoinvasion has been
related with increased risk of lympho-vascular space invasion (LVSI) and lymph node …

Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid
endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10 …

Abstract Microcystic, elongated, fragmented (MELF) pattern of myometrial invasion has been
proposed as a prognostic marker in patients with endometrial carcinoma (EC). Its prognostic …

In endometrioid endometrial carcinomas (EECs), microcystic, elongated, and fragmented
(MELF) myoinvasion is associated with easily overlooked lymph node metastases; however …

At the invasive front of adenocarcinomas, single cells and multicellular structures exist; the
latter include glands and cell clusters, such as tumor buddings and poorly differentiated …

Aim As a special invasive pattern seen in low‐grade endometrial carcinoma, microcystic,
elongated and fragmented (MELF) pattern is related to lymph node metastasis. Tumor …

Endometrioid endometrial carcinoma has an overall good prognosis. However, variable five-
year survival rates (92%-42%) have been reported in FIGO stage I, suggesting the …