Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of
the immune system and leads to the photoaging state which is reminiscent of chronological …

UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left
unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

This review article focuses on a critical survey of the main available information on the UVB
and UVA oxidative reactions to cellular DNA as the result of direct interactions of UV …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …

The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a
steady, predictable decline in lung function over time. Recent evidence suggests that some …

Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through
ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal …