Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative
phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might …

Abstract Three‐dimensional (3D) cultures of human pluripotent stem cell derived
cardiomyocytes (hPSC‐CMs) hold great promise for drug discovery, providing a better …

Mitochondria play pivotal roles in most eukaryotic cells, ranging from energy production to
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …

The first member of the uncoupling protein (UCP) family, brown adipose tissue uncoupling
protein 1 (UCP1), was identified in 1976. Twenty years later, two closely related proteins …

The growing focus on brown adipocytes has spurred an interest in their potential benefits for
metabolic diseases. Brown and beige (or brite) adipocytes express high levels of uncoupling …

Aberrant histone methylation profile is reported to correlate with the development and
progression of NAFLD during obesity. However, the identification of specific epigenetic …

Mitochondria are critical hubs for the integration of several key metabolic processes
implicated in cell growth and survival. They originated from bacterial ancestors through …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …