G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …

Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

Tumor microenvironment-targeted therapies are emerging as promising treatment options
for different cancer types. Tumor-associated macrophages and microglia (TAMs) represent …

Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

The entire world has been affected by the outbreak of COVID-19 since early 2020. Human
carriers are largely the spreaders of this new disease, and it spreads much faster compared …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Alcohol abuse and alcohol dependence are key factors in the development of alcohol use
disorder, which is a pervasive societal problem with substantial economic, medical, and …

Metabotropic receptors are responsible for so-called 'slow synaptic transmission'and
mediate the effects of hundreds of peptide and non-peptide neurotransmitters and …

Traditional antidepressants largely interfere with monoaminergic transport or degradation
systems, taking several weeks to have their therapeutic actions. Moreover, a large …

The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a
small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance …