Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Synonymous but not silent: the codon usage code for gene expression and protein folding

Y Liu, Q Yang, F Zhao - Annual review of biochemistry, 2021 - annualreviews.org
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity

X Wang, Y Guo, G Chen, E Fang, J Wang, Q Li, D Li… - Oncogene, 2023 - nature.com
Malate-aspartate shuttle (MAS) is essential for maintaining glycolysis and energy
metabolism in tumors, while its regulatory mechanisms in neuroblastoma (NB), the …

RNA polymerase III subunit mutations in genetic diseases

E Lata, K Choquet, F Sagliocco, B Brais… - Frontiers in Molecular …, 2021 - frontiersin.org
RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …

ALL-tRNAseq enables robust tRNA profiling in tissue samples

C Scheepbouwer, E Aparicio-Puerta… - Genes & …, 2023 - genesdev.cshlp.org
Transfer RNAs (tRNAs) are small adaptor RNAs essential for mRNA translation. Alterations
in the cellular tRNA population can directly affect mRNA decoding rates and translational …

Emerging roles of tRNA in cancer

D Ren, Y Mo, M Yang, D Wang, Y Wang, Q Yan, C Guo… - Cancer Letters, 2023 - Elsevier
Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and
abnormality of tRNAs directly leads to translation disorders and causes diseases, including …

tRNA function and dysregulation in cancer

T Gupta, MG Malkin, S Huang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Transfer RNA (tRNA) is a central component of protein synthesis and plays important roles
in epigenetic regulation of gene expression in tumors. tRNAs are also involved in many cell …

Applications of CRISPR-Cas9 technology to genome editing in glioblastoma multiforme

N Al-Sammarraie, SK Ray - Cells, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is an aggressive malignancy of the brain and spinal cord
with a poor life expectancy. The low survivability of GBM patients can be attributed, in part, to …

GBE1 promotes glioma progression by enhancing aerobic glycolysis through inhibition of FBP1

Z Chen, H Bao, J Long, P Zhao, X Hu, H Wang… - Cancers, 2023 - mdpi.com
Simple Summary Due to the poor prognosis of glioma patients and the limitations of glioma
treatment, our study aimed to find new targets for glioma on metabolic therapy. Our study …

Genes enriched in A/T-ending codons are co-regulated and conserved across mammals

H Benisty, X Hernandez-Alias, M Weber… - Cell Systems, 2023 - cell.com
Codon usage influences gene expression distinctly depending on the cell context. Yet, the
importance of codon bias in the simultaneous turnover of specific groups of protein-coding …