A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

Background. To cure ischemic diseases, angiogenesis needs to be improved by various
strategies in ischemic area. Considering that microRNA‐132 (miR‐132) regulates …

Background The mechanisms underpinning the regenerative capabilities of mesenchymal
stem cells (MSC) were originally thought to reside in their ability to recognise damaged …

Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen
species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems …

The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies
following myocardial infarction (MI) is hampered by the limited regeneration capacity of adult …

Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive
changes of the vessel wall through, among others, cell proliferation and migration, but also …

Antioxidants are endogenous and exogenous substances with the ability to inhibit oxidation
processes by interacting with reactive oxygen species (ROS). ROS, in turn, are small, highly …

Non-coding RNAs are functional RNA molecules comprising the majority of human
transcriptome. Only about 1.5% of the human genome is transcribed into messenger RNAs …

Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial
cells, and increasing its expression is a potential treatment for heart failure. Here, we report …