The ability to store and retrieve learned information over prolonged periods of time is an
essential and intriguing property of the brain. Insight into the neurobiological mechanisms …

Neuronal ensembles are local, sparsely distributed populations of neurons that are reliably
re-activated by a specific stimulus, context or task. Such discrete cell populations can be …

Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn
their behavioral relevance and across seconds when animals switch attention. While both …

The prelimbic cortex is involved in operant reward seeking. However, the precise nature of
its activity patterns and whether/how they differ between different types of rewards are …

Understanding the neurobiology of complex behaviors requires measurement of activity in
the discrete population of active neurons, neuronal ensembles, which control the behavior …

Non-overlapping cell populations within dorsomedial prefrontal cortex (dmPFC), defined by
gene expression or projection target, control dissociable aspects of reward seeking through …

Persistent susceptibility to cue-induced relapse is a cardinal feature of addiction.
Discriminative stimuli (DSs) are one type of drug-associated cue that signal drug availability …

Immediate-early gene (IEG) expression has been used to identify small neural ensembles
linked to a particular experience, based on the principle that a selective subset of activated …

Memories allow past experiences to guide future decision making and behavior. Sparse
ensembles of neurons, known as engrams, are thought to store memories in the brain. Most …

The parietal cortex of rodents participates in sensory and spatial processing, movement
planning, and decision-making, but much less is known about its role in associative learning …