Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

The vertebrate collagen superfamily now includes over 50 collagens and collagen-like
proteins. Here, their different structures are described, as well as their diverse forms of …

Recent research has shown that Coronavirus (CoV) replication depends on active
immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited …

Ubiquitin-mediated proteolysis is an integral part of diverse cellular functions, and of the
three enzymes involved in linking ubiquitin to protein targets, the E3 ubiquitin ligases are of …

We describe a novel function for the interferon (IFN)-induced protein 44-like (IFI44L) gene in
negatively modulating innate immune responses induced after virus infections. Furthermore …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …

Skin is the largest organ in the body and serves important barrier, regulatory, and sensory
functions. The epidermal layer shows rhythmic physiological responses to daily …

Very-long-chain fatty acids (VLCFAs) are essential for many aspects of plant development
and necessary for the synthesis of seed storage triacylglycerols, epicuticular waxes, and …

Cyclosporine (CsA) and its derivatives potently suppress hepatitis C virus (HCV) replication.
Recently, CsA-resistant HCV replicons have been identified in vitro. We examined the …