The current diagnostic criteria for pediatric onset multiple sclerosis (POMS) are summarized,
as well as the evidence for performance of the most recent iteration of McDonald criteria in …

Abstract Purpose of Review Multiple sclerosis is a chronic inflammatory disease of the
central nervous system. When seen in children and adolescents, crucial stages of brain …

New evidence and consensus has led to further revision of the McDonald Criteria for
diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of …

Brain imaging characteristics of MOG antibody disease are largely unknown and it is unclear
whether they differ from those of multiple sclerosis and AQP4 antibody disease. The aim of …

New therapies are being evaluated by clinical trials and, if efficacious, introduced for the
treatment of adult MS. The role of these new and existing agents in the management of …

Objective: To assess the evolution of cognitive and psychosocial functioning in a cohort of
childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had …

Importance With few approved multiple sclerosis therapies in the pediatric population, there
is a need for further approved treatment options. Limited data exist for dimethyl fumarate …

Incomplete relapse recovery contributes to disability accrual and earlier onset of secondary
progressive multiple sclerosis. We sought to investigate the effect of age on relapse …

The purpose of this study was to compare the clinical and quantitative magnetic resonance
imaging metrics of paediatric-onset multiple sclerosis to adult-onset multiple sclerosis. It was …

Objective The impetus for this consensus discussion was to recommend clinical trial designs
that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable …