The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases

HM Blevins, Y Xu, S Biby, S Zhang - Frontiers in aging neuroscience, 2022 - frontiersin.org
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Review of shikonin and derivatives: isolation, chemistry, biosynthesis, pharmacology and toxicology

S Yadav, A Sharma, GA Nayik, R Cooper… - Frontiers in …, 2022 - frontiersin.org
Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus
Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the …

Preparation of gelatin/carrageenan-based color-indicator film integrated with shikonin and propolis for smart food packaging applications

S Roy, JW Rhim - ACS Applied Bio Materials, 2020 - ACS Publications
Gelatin/carrageenan-based functional intelligent film was fabricated by incorporating
shikonin and propolis. The shikonin solution extracted from the gromwell (Lithospermum …

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Q Sun, T Gong, M Liu, S Ren, H Yang, S Zeng, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

Effect of blended colorants of anthocyanin and shikonin on carboxymethyl cellulose/agar-based smart packaging film

S Roy, HJ Kim, JW Rhim - International Journal of Biological …, 2021 - Elsevier
Natural colorants (anthocyanin and shikonin) were blended in different ratios (3: 1 and 1: 3)
and used for the preparation of carboxymethyl cellulose (CMC)/agar-based functional …

Synthesis of carboxymethyl cellulose and agar-based multifunctional films reinforced with cellulose nanocrystals and shikonin

S Roy, HJ Kim, JW Rhim - ACS Applied Polymer Materials, 2021 - ACS Publications
Multifunctional carboxymethyl cellulose/agar-based smart films were fabricated combining
cellulose nanocrystals (CNC) separated from onion peel and shikonin isolated from the …

Fabrication of cellulose nanofiber-based functional color indicator film incorporated with shikonin extracted from Lithospermum erythrorhizon root

S Roy, JW Rhim - Food Hydrocolloids, 2021 - Elsevier
Cellulose nanofiber (CNF)-based functional films were prepared by adding shikonin
extracted from dried roots of gromwell (Lithospermum erythrorhizon) using a solution casting …

Starch and agar-based color-indicator films integrated with shikonin for smart packaging application of shrimp

P Ezati, JW Rhim - ACS Food Science & Technology, 2021 - ACS Publications
Shikonin extracted from Lithospermum erythrorhizon was employed to develop pH-
indicating biodegradable starch-and agar-based films using a solution casting method. The …

Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

C Liu, L He, J Wang, Q Wang, C Sun, Y Li, K Jia… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Zicao is the dried root of Lithospermum erythrorhizon Sieb,
et Zucc, Arnebia euchroma (Royle) Johnst, or Arnebia guttata Bunge and commonly used to …

[HTML][HTML] Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms

Y Guo, M Zhou, Z Mu, J Guo, Y Hou, Y Xu… - Biomedicine & …, 2023 - Elsevier
Shikonin, the primary active compound found in the rhizome of the traditional Chinese
medicinal herb known as “ZiCao”, exhibits a diverse range of pharmacological effects. This …