Chiral Gd-DOTA as a Versatile Platform for Hepatobiliary and Tumor Targeting MRI Contrast Agents
W Xu, X Ye, M Wu, X Jiang, LH Hugo TSE… - Journal of Medicinal …, 2023 - ACS Publications
The leakage of gadolinium ions (Gd3+) from commercial Gd3+-based contrast agents
(GBCAs) in patients is currently the major safety concern in clinical magnetic resonance …
(GBCAs) in patients is currently the major safety concern in clinical magnetic resonance …
Lipophilic Group-Modified Manganese (II)-Based Contrast Agents for Vascular and Hepatobiliary Magnetic Resonance Imaging
Z Cai, L Jiang, Y Cao, S Fu, S Wang… - Journal of Medicinal …, 2024 - ACS Publications
Effective vascular and hepatic enhancement and better safety are the key drivers for
exploring gadolinium-free hepatobiliary contrast agents. Herein, a facile strategy proposes …
exploring gadolinium-free hepatobiliary contrast agents. Herein, a facile strategy proposes …
Design and synthesis of chiral DOTA-based MRI contrast agents with remarkable relaxivities
J Zhang, L Dai, L He, A Bhattarai, CM Chan… - Communications …, 2023 - nature.com
Due to the adverse effects of de-metallation in past concerning FDA-approved gadolinium-
based contrast agents (GBCAs), researchers have been focusing on developing safer and …
based contrast agents (GBCAs), researchers have been focusing on developing safer and …
Achieving safe and high-performance gastrointestinal tract spectral CT imaging with small-molecule lanthanide complex
X Che, C Yang, L Pan, D Gu, G Dai, J Shu… - Biomaterials …, 2023 - spj.science.org
Background Non-intrusive imaging of gastrointestinal (GI) tract using computed tomography
(CT) contrast agents is of the most significant issues in the diagnosis and treatment of GI …
(CT) contrast agents is of the most significant issues in the diagnosis and treatment of GI …
Rational Design of Mono-Substituted Gd-DOTA as Highly Stable and Efficient MRI Contrast Agents for Hepatobiliary and Inflammation Imaging
Y Ding, X Ruan, K Shu, W Xu, Y Liu, G Mo… - Journal of Medicinal …, 2024 - ACS Publications
Hepatobiliary-specific magnetic resonance imaging contrast agents (MRI CAs) play a crucial
role in the early diagnosis of hepatocellular carcinoma (HCC). However, only two acyclic …
role in the early diagnosis of hepatocellular carcinoma (HCC). However, only two acyclic …
Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents
Y Jian, G Mo, W Xu, Y Liu, Z Zhang, Y Ding… - Inorganic …, 2024 - ACS Publications
In recent years, pyclen-based complexes have attracted a great deal of interest as magnetic
resonance imaging (MRI) contrast agents (CAs) and luminescent materials, as well as …
resonance imaging (MRI) contrast agents (CAs) and luminescent materials, as well as …
Enhanced sensitivity of spectral CT imaging in vivo by using Ytterbium chelate
C Yang, D Gu, X Zhu, P Han, L Pan, X Che… - Chemical Engineering …, 2024 - Elsevier
Spectral CT can overcome the shortcomings of conventional CT, however, clinically used
iodized contrast agents are not ideal for spectral CT imaging, which calls for the …
iodized contrast agents are not ideal for spectral CT imaging, which calls for the …
A novel albumin-binding macrocyclic Gd-HPDO3A complex bearing a deoxycholic acid residue: the role of the hydration state, water exchange and local dynamics in …
F Hasallari, C Carrera, E Cavallari… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Gd-HPDO3A (ProHance, Bracco) appears to be one of the MRI contrast agents with the
lowest level of gadolinium retention in the body. Recently, we reported the synthesis and …
lowest level of gadolinium retention in the body. Recently, we reported the synthesis and …