Adverse effects of perinatal nicotine exposure on reproductive outcomes

MK Wong, NG Barra, N Alfaidy, DB Hardy… - …, 2015 - rep.bioscientifica.com
Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement
therapies or e-cigarette use continues to be a widespread public health problem, impacting …

Polycyclic aromatic hydrocarbons (PAHs) may explain the paradoxical effects of cigarette use on preeclampsia (PE)

JA Holme, H Valen, BC Brinchmann, GE Vist… - Toxicology, 2022 - Elsevier
Tobacco smoking and use of snus (smokeless tobacco) are associated with adverse effects
on pregnancy and neonatal outcomes. Nicotine is considered a key toxicant involved in …

Smoking and use of electronic cigarettes (vaping) in relation to preterm birth and small-for-gestational-age in a 2016 US national sample

X Wang, NL Lee, I Burstyn - Preventive medicine, 2020 - Elsevier
Women who smoke may be motivated to switch to vaping (use electronic cigarettes, e-cigs)
around pregnancy in seeking to alleviate known hazards of smoking. E-cigs typically contain …

Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies

AC Holloway, A Salomon, MJ Soares… - American Journal …, 2014 - journals.physiology.org
In utero exposure to nicotine is associated with increased risk of numerous adverse fetal and
neonatal outcomes, which suggests that it acts directly to affect placental development and …

Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic–pituitary–adrenal axis-associated …

D Xu, G Liang, YE Yan, WW He, YS Liu, LB Chen… - Toxicology letters, 2012 - Elsevier
Fetuses with intrauterine growth retardation (IUGR) induced by prenatal nicotine exposure
are susceptible to adult metabolic syndrome. Our goals for this study were to investigate the …

Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

N El-Merhie, A Krüger, K Uliczka, S Papenmeier… - Scientific Reports, 2021 - nature.com
E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes,
leading more and more women to switch from regular cigarettes to ENDS (electronic …

Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta

MK Wong, CJ Nicholson, AC Holloway, DB Hardy - PloS one, 2015 - journals.plos.org
Maternal nicotine exposure has been associated with many adverse fetal and placental
outcomes. Although underlying mechanisms remain elusive, recent studies have identified …

Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal …

Y Deng, H Cao, F Cu, D Xu, Y Lei, Y Tan… - Toxicology and Applied …, 2013 - Elsevier
Previous studies have confirmed that maternal tobacco smoking causes intrauterine growth
retardation (IUGR) and skeletal growth retardation. Among a multitude of chemicals …

Nicotine directly induces endoplasmic reticulum stress response in rat placental trophoblast giant cells

MK Wong, AC Holloway, DB Hardy - Toxicological Sciences, 2016 - academic.oup.com
Nicotine exposure during pregnancy leads to placental insufficiency impairing both fetal and
neonatal development. Previous studies from our laboratory have demonstrated that in rats …

Prenatal nicotine exposure retards osteoclastogenesis and endochondral ossification in fetal long bones in rats

H Hu, X Zhao, J Ma, Y Shangguan, Z Pan, L Chen… - Toxicology letters, 2018 - Elsevier
This study investigated the mechanisms underlying the retarded development of long bone
in fetus by prenatal nicotine exposure (PNE) which had been demonstrated by our previous …