Embryo implantation into the uterus marks a key transition in mammalian development. In
mice, implantation is mediated by the trophoblast and is accompanied by a morphological …

Research on early postimplantation mammalian development has been limited by the small
size and intrauterine confinement of the developing embryos. Owing to the inability to …

The complex process by which a single-celled zygote develops into a viable embryo is
nothing short of a miraculous wonder of the natural world. Elucidating how this process is …

Advancements in methods that enable in vitro culture of mammalian embryos have become
an essential way of investigating mammalian early embryonic development and modeling …

The fundamental physical features such as the mechanical properties and microstructures of
the uterus need to be considered when building in vitro culture platforms to mimic the uterus …

Gastruloids have emerged as highly useful in vitro models of mammalian gastrulation. One
of the most striking features of 3D gastruloids is their elongation, which mimics the extension …

The formation of a central lumen in the human epiblast is a critical step for development.
However, because the lumen forms in the epiblast coincident with implantation, the …

Tissue patterning coordinates morphogenesis, cell dynamics and fate specification.
Understanding how these processes are coupled to achieve precision despite their inherent …

The blastocyst forms during the first days of mammalian development. The structure of the
blastocyst is conserved among placental mammals and is paramount to the establishment of …

bromoacetamide (BAcAm), a new class of disinfection by-products (DBPs), is widely
detected in drinking water across the world. Reports of the high cytogenetic toxicity of …