The unique advantages and the exciting application prospects of AIEgens have triggered
booming developments in this area in recent years. Among them, stimuli‐responsive …

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular
turnover. There is growing evidence that the ageing of the immune system is initiated at the …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

The decline in hematopoietic function seen during aging involves a progressive reduction in
the immune response and an increased incidence of myeloid malignancy, and has been …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

Upon aging, hematopoietic stem cells (HSC s) undergo changes in function and structure,
including skewing to myeloid lineages, lower reconstitution potential and loss of protein …

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain
homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is …

Compared to normal cells, cancer cells require more energy supply during proliferation and
metabolism. In living cells, in addition to mitochondria, lipid droplets are also an important …

Many elderly people suffer from hematological diseases known to be highly age-dependent.
Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells …