Current strategies for exosome cargo loading and targeting delivery

H Zeng, S Guo, X Ren, Z Wu, S Liu, X Yao - Cells, 2023 - mdpi.com
Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …

Immunogenicity of extracellular vesicles

Y Xia, J Zhang, G Liu, J Wolfram - Advanced Materials, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery
systems due to demonstrated safety and efficacy in preclinical models and early‐stage …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment

T Lu, Z Zhang, J Zhang, X Pan, X Zhu… - Journal of …, 2022 - Wiley Online Library
Research on tumour cell‐derived small extracellular vesicles (sEVs) that regulate tumour
microenvironment (TME) has provided strategies for targeted therapy of head and neck …

[HTML][HTML] Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1

CH Lee, JH Bae, EJ Choe, JM Park, SS Park… - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) carrying tumor cell-derived programmed death-ligand 1 (PD-L1)
interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a …

Cause and consequence of heterogeneity in human mesenchymal stem cells: challenges in clinical application

Z Lyu, M Xin, DR Oyston, T Xue, H Kang… - … -Research and Practice, 2024 - Elsevier
Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-
proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility …

Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Application of Single Extracellular Vesicle Analysis Techniques

J Zhu, F Wu, C Li, J Mao, Y Wang, X Zhou… - International Journal …, 2023 - Taylor & Francis
Extracellular vesicles (EVs) are lipid containers that are actively released by cells and
contain complex molecular cargoes. These cargoes include abundant material such as …

Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)

N Prakash, J Kim, J Jeon, S Kim, Y Arai… - Biomaterials …, 2023 - spj.science.org
The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past
decade. Their multilineage differentiation potentials and immunomodulatory properties have …

Engineered extracellular vesicles in wound healing: design, paradigms, and clinical application

Y Liao, Z Zhang, L Ouyang, B Mi, G Liu - Small, 2024 - Wiley Online Library
The severe quality of life and economic burden imposed by non‐healing skin wounds,
infection risks, and treatment costs are affecting millions of patients worldwide. To mitigate …