Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at
regions of disturbed blood flow and is triggered by an interplay between endothelial …

Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …

Cells are covered by a surface layer of glycans that is referred to as the 'glycocalyx'. In this
review, we focus on the role of the glycocalyx in vascular diseases (atherosclerosis, stroke …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

Purpose In 2007 the two senior authors wrote a review on the structure and function of the
endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9: 121–167, 2007). Since …

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier
between circulating blood and the vessel wall. The glycocalyx is suggested to play an …

The endothelial glycocalyx (EG), which covers the apical surface of the endothelial cells and
floats into the lumen of the vessels, is a key player in vascular integrity and cardiovascular …