Purpose A range of interventions have been used for the management of Chronic Fatigue
Syndrome/Myalgic Encephalomyelitis (CFS/ME) in children and adolescents. Currently …

Importance Chronic fatigue syndrome (CFS) is a disabling condition with unknown disease
mechanisms and few treatment options. Objective To explore the pathophysiology of CFS …

Objective To provide an overview of non-parenteral clonidine formulations and assess the
feasibility of their use for paediatric sedation. Methods A literature search was conducted …

Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and
epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase …

Abstract Background The Oslo Study of Clonidine in Elderly Patients with Delirium (LUCID)
is an RCT investigating the effect of clonidine in medical patients> 65 years with delirium. To …

Abstract Background Chronic Fatigue Syndrome (CFS) is a common and disabling condition
in adolescence with few treatment options. A central feature of CFS is orthostatic intolerance …

Background Delirium affects 15% of hospitalised patients and is linked with poor outcomes,
yet few pharmacological treatment options exist. One hypothesis is that delirium may in part …

Functional disorders (FDs) can often be managed with non-pharmacologic therapies. When
drug therapy is employed, selection of medications should be based on the primary …

Background Delirium is often also called “acute confusional state” and is characterized by
an acute decline in attention and cognition. Delirium is common, and as many as 20% of …